NameSIRT1
OrganismMus musculus (cell culture)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainC57BL/6 x 129
DescriptionSIRT1 knock-out MEFs have a significantly greater replicative capacity in culture than wild type MEFs (Chua et al., 2005).
Gene FunctionNAD-dependent protein deacetylase (Imai et al., 2000).
Other Phenotypesp19ARF levels are significantly reduced in SIRT1 knock-out MEFs (Chua et al., 2005).
HomologsS.c. SIR2, HST1, HST2, HST3, HST4
S.p. Spbc16D10.07c, Spcc132.02, hst4
C.e. Sir-2.1, F46G10.3, F46G10.7, C06A5.3
D.m. sir2, CG6284, CG3187
R.n. SIRT2
M.m. SIRT2, SIRT3, SIRT4, SIRT5, SIRT6
H.s. SIRT3, SIRT2, SIRT5, SIRT4, SIRT6
Primary ReferenceChua, K. F., Mostoslavsky, R., Lombard, D. B., Pang, W. W., Saito, S., Franco, S., Kaushal, D., Cheng, H., Fischer, M. R., Stokes, N., et al. (2005). Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2, 67-76
Other ReferencesImai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase. Nature 403, 795-800. [Abstract]
Relevant LinksEntrezGene: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=93759
KeywordsSirtuins, Sir2