InterventionMethionine restriction
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
Strain(BALB/c x C57BL/6) F1 mice
DescriptionDietary restriction of methionine from 0.43% to 0.15% results in a significant increase in maximum lifespan (Miller et al., 2005). Due to early death in the methionie restricted group, if only those mice suriviving at least 1 year are included in the analysis, both median and maximum lifespan is extended by methionine restriction.
Gene FunctionL-methionine is an essential amino acid.
Other PhenotypesDietary restriction of methionine in mice results in significantly lower levels of serum IGF-1, insulin, glucose, and thyroid hormone (Miller et al., 2005).
Dietary methionine restriction has previously been shown to increase lifespan in rats (Orentreich et al., 1993).
Primary ReferenceMiller, R. A., Buehner, G., Chang, Y., Harper, J. M., Sigler, R., and Smith-Wheelock, M. (2005). Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF leve [Abstract]
Other ReferencesOrentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]
Relevant Links
Keywordscalorie restriction, caloric, diet, nutrition, amino acid, protein,