NameMitochonrdially targeted human catalase
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainC57BL/6J
DescriptionOverexpression of human catalase in mitochondria increases mean and maximum life-span by approximately 20% in mice (Schriner et al., 2005). Inactivation of aconitase in heart mitochondria and mitochondrial DNA damage was also reduced in long-lived animals.
Gene FunctionCatalase, converts hydrogen peroxide to water.
Other PhenotypesOverexpression of both superoxide disumutase and catalase increases life span in flies (Orr and Sohal, 1994).
HomologsS.c. CTA1, CTT1
S.p. CTA1
C.e. CTL-1, CTL-2, CTL-3
D.m. CAT
R.n. CAT
M.m. CAT
Primary ReferenceSchriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Wallace, D. C., and Rabinovitch, P. S. (2005). Overexpression of Mitochondrial-Targeted Catalase Extends Murine Life Span.
Other ReferencesOrr, W. C., and Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-30. [Abstract]
Relevant Links
Keywordsoxidative stress, mitochondria, free radical theory of aging, mouse