InterventionResveratrol
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainPSY316, BY4742, W303R
DescriptionResveratrol from two different sources (Biomol and Sigma)was found to have no effect on replicative lifespan in three different strain backgrounds: PSY316, BY4742, and W303R (Kaeberlein et al., 2005). This differs from a previous study, in which resveratrol was reported to increase lifespan by 70% in the PSY316 strain background (Howitz et al., 2003).
Gene FunctionResveratrol is an antioxidant found in red wine.
Other PhenotypesActivation of Sir2-family member proteins (Sirtuins) by resveratrol appears to be specific for substrates containing Fluor de Lys, a fluorophore used in drug screening (Kaeberlein et al., 2005).
Homologs
Primary ReferenceKaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S., Napper, A., Curtis, R., Distefano, P. S., Fields, S., et al. (2005). Substrate specific activation fo sirtuins by resveratrol. J Biol Chem. [Abstract]
Other ReferencesHowitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-1 [Abstract]
Relevant Links
Keywordsyeast, caloric restriction, calorie restriction, CR, rDNA, silencing, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae, chromatin, DNA, metabolism, NAD, ranscription