InterventionAblation of dilp2 producing neurosecretory cells
Alternate Namedilp2
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeDeletion
Strainwhite Dahomey
DescriptionAblation of neurosecretory brain cells that produce the insulin-like peptide dilp2 increases median lifespan by 18-33% (Broughton et al., 2005).
Gene FunctionInsulin-like peptide
Other PhenotypesAnimals in which dilp2 producing cells had been ablated showed increased fasting glucose levels, increased storage of lipid and carbohydrate, reduced fecundity,and reduced tolerance of heat and cold, as well as increased resistance to oxidative stress and starvation (Broughton et al., 2005).
Homologs
Primary ReferenceBroughton, S. J., Piper, M. D., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., and Partridge, L. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of [Abstract]
Broughton, S. J., Piper, M. D., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., and Partridge, L. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of [Abstract]
Other References
Relevant Links
Keywordsinsulin, calorie restriction, caloric, fly