Namenhr-49
OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRNAi
StrainN2
DescriptionRNAi knock-down of nhr-49 shortens life-span by 30-40%. A mutant allele, nhr-49(nr2041) results in an even shorter life-span (Van Gilst et al., 2005).
Gene FunctionNuclear hormone receptor.
Other PhenotypesNhr-49 mutant animals accumulate fat, due to decreased expression of enzymes involved in fatty acid beta-oxidation (Van Gilst et al., 2005).
HomologsC.e. NHR-69, NHR-35, NHR-14 ...
D.m. HNF4, USP, HR39 ...
R.n. RXRA, RXRB, HNF4A ...
H.s. RXRB, RXRA, HNF4A ...
M.m. RXRA, RXRB, HNF4A ...
Primary ReferenceVan Gilst, M. R., Hadjivassiliou, H., Jolly, A., and Yamamoto, K. R. (2005). Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3, E53.
Other References
Relevant LinksWormBase: http://dev.wormbase.org/db/gene/gene?name=nhr-49
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172839
Keywordsworm, fat, metabolism