OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRecessive
DescriptionThe aak-2(ok524) allele shortens life-span by approximately 12% (Apfeld et al., 2004).
Gene FunctionAMP-activated protein kinase
Other PhenotypesA lipofuscin-like fluorescent pigment that accumulates in an age-dependent manner in the intestine accumulates faster in aak-2 mutants, consistent with the idea that aak-2 mutation accelerates aging (Apfeld et al., 2004).
HomologsS.c. SNF1
C.e. aak-2
D.m. SNF1A
H.s. AMPKalpha1
Primary ReferenceApfeld, J., O'Connor, G., McDonagh, T., Distefano, P. S., and Curtis, R. (2004). The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. [Abstract]
Other References
Relevant Links
KeywordsATP, energy, calorie restriction, caloric restriction, worm