OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionDeletion of SCH9 increases replicative life-span by 18% (Fabrizio et al., 2004).
Gene FunctionProtein kinase involved in nutrient signalling and stress response.
Other PhenotypesDisruption of SCH9 extends chronological life-span, as measured by stationary phase survival, up to 300% (Fabrizio et al., 2001).
HomologsS. c. Ypk2p; Ypk1p; Tpk3p
S. p. Sck1p; Sck2p
C. e. C12D8.10A; W10G6.2; AKT-2
D. m. AKT1; PKC98E; S6KII
R. n. AKT2; AKT; RN.10506
M. m. AKT; AKT2; AKT3
H. s. AKT1; AKT2; PKBG
Primary ReferenceFabrizio, P., Pletcher, S. D., Minois, N., Vaupel, J. W., and Longo, V. D. (2004). Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett 557, 136-142. [Abstract]
Other ReferencesFabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-90. [Abstract]
Relevant LinksSGD:
Keywordsheat shock, yeast, Saccharomyces cerevisiae, oxidative stress, stationary phase, replicative senescence