NameNR3C1
OrganismHomo sapiens
Aging PhenotypeCorrelation
Allele TypeN/A
StrainMen from Zoetermeer, The Netherlands
DescriptionThe ER22/23EK variant of nuclear receptor subfamily 3 group C member 1 (glucocorticoid receptor), is correlated with longevity in males (van Rossum et al., 2004).
Gene FunctionGlucocorticoid receptor
Other PhenotypesThe ER22/23EK allele is associated with relative glucocorticoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels (van Rossum et al., 2004).
HomologsC.e. NHR-17, NHR-31, NHR-69 ...
D.m. ERR, ECR , SVP, HR38 ...
R.n. NR3C1, MLR, PGR, AR ...
M.m. NR3C1, PGR, AR, ESRRG ...
H.s. NR3C2, PGR, AR, ESRRG ...
Primary Referencevan Rossum, E. F., Feelders, R. A., van den Beld, A. W., Uitterlinden, A. G., Janssen, J. A., Ester, W., Brinkmann, A. O., Grobbee, D. E., de Jong, F. H., Pols, H. A., et al. (2004). Association of the ER22/23EK polymorphism in the glucocorticoid receptor [Abstract]
Other References
Relevant LinksLocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=2908
OMIM: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138040
Keywordshormonal, signalling, heart disease, human, diabetes, inflammatory response