OrganismHomo sapiens
Aging PhenotypeCorrelation
Allele TypeN/A
StrainIndividuals from Calabria, Italy
DescriptionIn a study of individuals from Calabria, Italy, the TT genotype of a silent G/T transversion (G477T) in the SIRT3 gene was found to correlate with longevity in males, but not females (Rose et al., 2003).
Gene FunctionNAD-dependent protein deacetylase.
Other PhenotypesSIRT3 is localized to mitochondrial (Onyango et al., 2002; Schwer et al., 2002).
SIRT3 is a member of the Sir2-family of proteins (Sirtuins), which promote longevity in yeast (Kaeberlein et al., 1999) and worms (Tissenbaum and Gaurente, 2001).
HomologsS.c. HST2, SIR2, HST1, HST4
C.e. SIR-2.1, SIR-2.2, ...
D.m. SIRT2, SIR2, SIRT4 ...
M.m. SIRT3, SIRT2, SIRT1 ...
H.s. SIRT2, SIRT1, SIRT6...
Primary ReferenceRose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V., Passarino, G., Feraco, E., Mari, V., Barbi, C., et al. (2003). Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp G [Abstract]
Other ReferencesOnyango, P., Celic, I., McCaffery, J. M., Boeke, J. D., and Feinberg, A. P. (2002). SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A 99, 13653-13658. [Abstract]
Schwer, B., North, B. J., Frye, R. A., Ott, M., and Verdin, E. (2002). The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158, 647-657. [Abstract]
Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Tissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230. [Abstract]
Relevant LinksOMIM:
Keywordsmetabolism, linkage, human, NAD