OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionReplacement of the C/EBP alpha gene with the C/EBP beta gene results in a 20% increase in mean life-span (Chiu et al., 2004).
Gene FunctionCCAAT enhancer binding protein involved in fat cell differentiation and maturation
Other PhenotypesBeta/beta animals consume more food but weigh less than control animals (Chen et al., 2000), and have a slightly elevated body temperature (0.3-0.5 degrees C) (Chiu et al., 2004).
Beta/beta animals show an increase in mitochondrial biogenesis only in fat cells from white adipose tissue (Chiu et al., 2004).
Primary ReferenceChiu, C. H., Lin, W. D., Huang, S. Y., and Lee, Y. H. (2004). Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev. [Abstract]
Other ReferencesChen, S. S., Chen, J. F., Johnson, P. F., Muppala, V., and Lee, Y. H. (2000). C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol 20, 7292-7299. [Abstract]
Relevant LinksLocusLink:
Keywordsadipocyte, mitochondria, calorie, caloric restriction, fat