NameSCP1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainKAY446
DescriptionDeletion of SCP1 increases life-span by approximately 67% (Gourlay et al., 2004).
Gene FunctionProtein that crosslinks and stabilizes actin filaments
Other PhenotypesOverexpression of SCP1 increases ROS production (Gourlay et al., 2004).
HomologsS.c. IGG1
S.p. Spac4f8.10c, Rng2
C.e. CPN-1, F28H1.2, D1069.2
D.m. MP20, CG5023, CHD64
R.n. TAGLN3 , TAGLN, CNN3 ...
M.m. TAGLN2, TAGLN3, TAGLN ...
H.s. NP25, TAGLN2, TAGLN ...
Primary ReferenceGourlay, C. W., Carpp, L. N., Timpson, P., Winder, S. J., and Ayscough, K. R. (2004). A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164, 803-809. [Abstract]
Other References
Relevant LinksYPD: http://db.yeastgenome.org/cgi-bin/SGD/locus.pl?locus=scp1
Keywordsaging, replicative, budding, yeast, mitochondrial, reactive oxygen species