Namelet-363
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainN2
DescriptionThe let-363(h111) allele has no significant effect on life-span (Jia et al., 2004).
Gene FunctionProtein serine/threonine kinase
Other PhenotypesLet-363 interacts with Daf-15. (Jia et al., 2004).
HomologsS.c. Tor2, Tor1, Mec1 ...
S.p. Tor2, Tor1p, Rad3p ...
C.e. SMG-1, ATL-1, ATM-1 ...
D.m. TOR, CG32743, CG6535...
R.n. FRAP1, PIK3CB, PIK3CA...
M.m. FRAP1, ATM, PRKDC ...
H.s. FRAP1, SMG1, ATR , ATM ...
Primary ReferenceJia, K., Chen, D., and Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=let-363
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172167
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, transcription factor, dauer, metabolism, caloric restriction, nutrient, TOR