Namedaf-15
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainN2
DescriptionMutations in daf-15 increase life span by15-30% (Jia et al., 2004). Life span extension is dependent on the Daf-16 transcription factor.
Gene FunctionTOR regulator protein
Other Phenotypesdaf-15 mutants are dauer constitutive (Jia et al., 2004).
HomologsN/A
N/A
Primary ReferenceJia, K., Chen, D., and Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=daf-15
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=267109
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, transcription factor, dauer, metabolism, caloric restriction, nutrient