Namehuman thioredoxin
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainC57BL/6
DescriptionTransgenic mice overexpressing human TXN (TRX-tg) had a median life-span that was 35% longer and a maximum life-span that was 22% greater than C57BL/6 wild-type controls (Matsui et al., 2002).
Gene FunctionThioredoxin
Other PhenotypesTelomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice (Mitsui et al., 2002).
HomologsS.c. Trx2, Trx3, Trx1 ...
S.p. Trx1, Trx2
C.e. B0228.5, Y55F3AR.2 ...
D.m. TRX-2, TXL, TRXT, DHD...
R.n. TXN, TXNL, TXN2 ...
M.m. TXN1, TXNDC2 ...
H.s. TXNDC2, TXNL1, TXN2 ...
Primary ReferenceMitsui, A., Hamuro, J., Nakamura, H., Kondo, N., Hirabayashi, Y., Ishizaki-Koizumi, S., Hirakawa, T., Inoue, T., and Yodoi, J. (2002). Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal 4, [Abstract]
Other References
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=7295
Keywordsantioxidant, ROS, reactive oxygen species, oxidative stress, mitochondria, redox, free radical, sulfur