|Aging Phenotype||Shortened life-span|
|Description||A hypomorphic deletion of helicase domains 3, 4, and part of 2, results in expression of a C-terminal truncated PASG protein causing an extrememly short life-span (Sun et al., 2004). 60% of homozygous mutants died shortly after birth, with the remaining 40% surviving up to several weeks (~25 days).|
|Gene Function||Proliferation associated SNF2-like gene. Helicase that regulates chromatin remodeling for methylation.|
|Other Phenotypes||Disruption of PASG results in genomic hypomethylation, de-repression of silenced genes, and premature aging, characterized by decreased proliferation, increased replicative senescence, and altered expression of bmi-1 and p16INK4a(Sun et al., 2004). PASG mutant mice also showed significant hypoglycemia, low birth weight and growth retardation, graying hair and balding, reduced fat deposition, unstable gait, cachexia, and kyphosis.|
|Homologs||S.c. Yfr038p, Isw2p, Snf2p...|
S.p. Snf21p, Hrp1p ...
C.e. CHD-3, H06O01.2, LET-418 ...
D.m. ISWI, KIS, BRM ...
R.n. SMARCA4, DDX49 ...
M.m. CHD1L, CHD4, SMARCAD1...
H.s. HELLS, CHD9, CHD8 ...
|Primary Reference||Sun, L. Q., Lee, D. W., Zhang, Q., Xiao, W., Raabe, E. H., Meeker, A., Miao, D., Huso, D. L., and Arceci, R. J. (2004). Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 18, 1035-1046. [Abstract]|
|Relevant Links||LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=15201|
|Keywords||Replicative senescence, karyotype instability, abnormal genomic methylation, premature aging, progeria, stochastic death|