InterventionResveratrol
Alternate Name
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainCanton-S
DescriptionTreatment of flies with resveratrol increased life-span by 16-20% (Wood et al., 2004).
Gene FunctionResveratrol is an antioxidant found in red wine that also activates Sirtuins.
Other Phenotypes10 uM resveratrol increases life-span by up to 70% in yeast (Howitz et al., 2003).
Homologs
Primary ReferenceWood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. [Abstract]
Other ReferencesHowitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-1 [Abstract]
Relevant Links
Keywordscaloric restriction, calorie restriction, CR, worms, flies, Sir2, antioxidant, yeast, deacetylase