InterventionResveratrol
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2
DescriptionTreatment with 100 uM resveratrol increases C. elegans life-span by approximately 10% (Wood et al., 2004). Resveratrol fails to increase life-span in a strain lacking Sir-2.1.
Gene FunctionResveratrol is an antioxidant found in red wine that also activates Sirtuins.
Other Phenotypes10 uM resveratrol increases life-span by up to 70% in yeast (Howitz et al., 2003).
Homologs
Primary ReferenceWood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. [Abstract]
Other ReferencesHowitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-1 [Abstract]
Relevant Links
Keywordscaloric restriction, calorie restriction, CR, worms, Sir2, insulin, antioxidant, yeast, deacetylase