|Description||Metabolic intensity (daily food energy/body mass) correlates with longevity in MF1 mice (Speakman et al., 2004). Animals with the highest quartile of metabolic intensities had a mean life-span 36% longer than animals with the lowest quartile of metabolic intensities. The high metabolism of long-lived animals could be attributed to increased uncoupling by UCP3.|
|Gene Function||Uncoupling protein 3, an uncoupler of oxidative phosphorylation.|
|Other Phenotypes||Skeletal muscle mitochondria isolated from high metabolism mice are more uncoupled than those from low metabolism mice (Speakman et al., 2004).|
|Homologs||S.c. DIC1, OAC1, YIL006 ...|
S.p. Spac139.02, Spac328.09 ...
C.e. B0432.4, K07B1.3 ...
D.m. UCP4A, BMCP, UCP4B ...
R.n. UCP3, UCP2, UCP1...
M.m. UCP2, UCP1, SLC25A14 ...
H.s. UCP3, UCP2, UCP1...
|Primary Reference||Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., and Brand, M. (2004). Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live|
|Relevant Links||LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=22229|
|Keywords||metabolism, metabolic rate,mitochondria, reactive oxygen species, electron transport, uncoupled, calorie restriction, caloric, mouse, rodent, mammals|