NameUCP3
OrganismMus musculus
Aging PhenotypeCorrelation
Allele TypeN/A
StrainMF1
DescriptionMetabolic intensity (daily food energy/body mass) correlates with longevity in MF1 mice (Speakman et al., 2004). Animals with the highest quartile of metabolic intensities had a mean life-span 36% longer than animals with the lowest quartile of metabolic intensities. The high metabolism of long-lived animals could be attributed to increased uncoupling by UCP3.
Gene FunctionUncoupling protein 3, an uncoupler of oxidative phosphorylation.
Other PhenotypesSkeletal muscle mitochondria isolated from high metabolism mice are more uncoupled than those from low metabolism mice (Speakman et al., 2004).
HomologsS.c. DIC1, OAC1, YIL006 ...
S.p. Spac139.02, Spac328.09 ...
C.e. B0432.4, K07B1.3 ...
D.m. UCP4A, BMCP, UCP4B ...
R.n. UCP3, UCP2, UCP1...
M.m. UCP2, UCP1, SLC25A14 ...
H.s. UCP3, UCP2, UCP1...
Primary ReferenceSpeakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., and Brand, M. (2004). Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live
Other References
Relevant LinksLocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=22229
Keywordsmetabolism, metabolic rate,mitochondria, reactive oxygen species, electron transport, uncoupled, calorie restriction, caloric, mouse, rodent, mammals