Namemrp-5
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainBristol N2
DescriptionRNAi of mrp-5 increases life-span by 38% (Lee et al., 2003).
Gene FunctionATP-binding cassette (ABC) transporter
Other PhenotypesRNAi of mrp-5 results in increased dauer formation and slow growth (Lee et al., 2003).
HomologsS.c. Ycf1, Bpt1, Yhl035 ...
S.p. Spac3f10.11c, Spbc359.05 ...
C.e. MRP-2, F20B6.3, E03G2.2...
D.m. CG4562, CG7627, CG31792 ...
R.n. ABCC5A, ABCC12, ABCC2 ...
M.m. ABCC5, ABCC1, ABCC10 ...
H.s. ABCC5, ABCC12, ABCC11 ...
Primary ReferenceLee, S. S., Kennedy, S., Tolonen, A. C., and Ruvkun, G. (2003). DAF-16 target genes that control C. elegans life-span and metabolism. Science 300, 644-647. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=mrp-5
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181587
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, caloric restriction, oxidative stress