Namepnk-1
OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRNAi
StrainBristol N2, CB1370;daf-2(e1370)
DescriptionRNAi of pnk-1 shortened life-span in both wild-type and daf-2 mutant animals (Lee et al., 2003).
Gene FunctionPantothenate kinase involved in coenzyme A biosynthesis.
Other PhenotypesRNAi of pnk-1 results in reduced lipid storage (Lee et al., 2003).
Transcription of pnk-1 is elevated in daf-2 mutants in a daf-16-dependent manner.
HomologsS.c. YDR531W
S.p. SPBC4B4.01c
D.m. CG5828
R.n. PANK4
C.e. UVT-3
M.m. PANK4, PANK2, PANK1...
H.s. FLJ10782, PANK1, PANK2...
Primary ReferenceLee, S. S., Kennedy, S., Tolonen, A. C., and Ruvkun, G. (2003). DAF-16 target genes that control C. elegans life-span and metabolism. Science 300, 644-647. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=pnk-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172327
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, caloric restriction, oxidative stress, fat, lipid