Namesgk-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of SGK-1 increases life-span by approximatley 60% (Hertweck et al., 2004). This life-span extension is suppressed by mutation of daf-16.
Gene FunctionProtein kinase with homology to mammalian serum/glucocorticoid regulated kinase
Other Phenotypessgk-1 RNAi animals have a severe egg-laying defect and show pleitropic phenotypes similar to mutants in daf-2, age-1, and pdk-1 (Hertweck et al., 2004).
HomologsS.c. YPK1, YPK2, SCH9 ...
S.p. GAD8, SCK1, SCK2 ...
C.e. AKT-1, KIN-1, AKT-2 ...
D.m. AKT1, PKC53E, PKA-C1...
R.n. SGK, SGK2, AKT3 ...
M.m. SGK, SGK3, SGK2, AKT3 ...
H.s. SGK, SGKL, SGK2, AKT3 ...
Primary ReferenceHertweck, M., Gobel, C., and Baumeister, R. (2004). C. elegans SGK-1 Is the Critical Component in the Akt/PKB Kinase Complex to Control Stress Response and Life Span. Dev Cell 6, 577-588. [Abstract]
Other References
Relevant LinksLocuslink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181697
WormBase: http://www.wormbase.org/db/gene/locus?name=sgk-1
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, oxidative stress,kinase,