Nameins-22
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptionins-22 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of ins-22 has no effect on life-span.
Gene FunctionInsulin/IGF-1-like peptide
Other Phenotypes
Homologs
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=ins-22
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=191690
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi