Interventionantioxidant drug EUK-134
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionTreatment of worms with 0.5 mM EUK-134 resulted in about 50% increase in mean and maximum life-span. Treatment also restores a normal life-span to mev-1 mutants, which accumulate oxidative damage during aging (Melov et al., 2000).
Gene FunctionEUK-134 acts as a superoxide dismutase and catalase mimetic (Baker et al., 1998).
Other PhenotypesTreatment with the drug did not affect fertility or body size (Melov et al., 2000).

EUK-134 treatment resulted in a shortened life-span in the house fly, Musca domestica (Bayne and Sohal, 2002).

Primary ReferenceMelov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., and Lithgow, G. J. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-9. [Abstract]
Other ReferencesBaker, K., Marcus, C. B., Huffman, K., Kruk, H., Malfroy, B., and Doctrow, S. R. (1998). Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ische [Abstract]
Bayne, A. V., and Sohal, R. S. (2002). Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica. Free Radic Biol Med 32, 1229-34. [Abstract]
Relevant LinksNone.
KeywordsCaenorhabditis, elegans, worm, oxidative stress