OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeDeletion
Strainrrf-3(pk 1426)
Descriptionpep-2 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of pep-2 increases life-span by 14%.
Gene FunctionIntestinal proton:peptide symporter
Other Phenotypespep-2 mutants display a decrease in fat content
HomologsS.c. PTR2
S.p. PTR2
C.e. PEP-1, F56F4.5, Y46C8AL.7
D.m. CG2930, YIN, CG9444
R.n. Slc15a1, Slc15a2, LOC246280, Pht2
M.m. us SLC15A2, SLC15A1, SLC15A4
H.s. SLC15A1, SLC15A2, SLC15A4
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksLocusLink:
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi