Namelbp-7
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptionlbp-7 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of lbp-7 increases life-span by 14%.
Gene FunctionPredicted fatty-acid binding protein.
Other Phenotypes
HomologsC.e. LBP-6, LBP-5, LBP-8 ...
R.n. FABP3, FABP4, FABP5...
M.m. FABP3, FABP4, FABP5 ...
H.s. FABP3, PMP2, FABP4
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=lbp-7
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=191701
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi