Namenuc-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptionnuc-1 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of nuc-1 increases life-span by 30%.
Gene FunctionEndonuclease involved in apoptotic DNA degradation (Parrish and Xue, 2003).
Other PhenotypesNull mutants display reduced fertility (Rinaldo et al, 2002).
HomologsC.e. crn-6, yls-2
D.m. DNASEII
R.n. DNASE2, DLAD
M.m. DNASE2B, DNASE2A
H.s. DLAD, DNASE2
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83 [Abstract]
Other ReferencesParrish, J. Z., and Xue, D. (2003). Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell 11, 987-96. [Abstract]
Rinaldo, C., Bazzicalupo, P., Ederle, S., Hilliard, M., and La Volpe, A. (2002). Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development. Genetics 160, 471-9. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=nuc-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181174
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi, apoptosis, DNA, reproduction