Namegcy-18
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptiongcy-18 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of gcy-18 increases mean life-span by 25%.
Gene FunctionUnknown
Other Phenotypes
HomologsS.c. CDC15, STE11, SSK22 ...
S.p. CDS1, WIS4, ARK1 ...
C.e. gcy-23, gcy-8, C04H5.3 ...
D.m. CG31183, CG3216, GYC76C ...
R.n. NPR1, NPR2, KSGC ...
M.m. NPR2, NPR1, GUCY2E ...
H.s. NPR2, NPR1, GUCY2F...
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=gcy-18
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178237
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi