Namevit-1
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptionvit-1 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). vit-1 RNAi animals have a mean life-span 103% that of control animals.
Gene FunctionUnknown.
Other Phenotypes
HomologsC.e. vit-2, vit-5, vit-4, vit-3, vit-6
R.n. MUC5AC
M.m. 3110056H04RIK, VWF
H.s. BMPER, FCGBP
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=vit-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181034
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi