Namevit-2
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 rrf-3(pk 1426)
Descriptionvit-2 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of vit-2 increases life-span by 20%.
Gene FunctionCholesterol transport (Matyash et al., 2001).
Other PhenotypesVit-2 functions in germ line development by regulating the abundance of native versus oxidized LDL-like lipoproteins (Matyash et al., 2001).
HomologsC.e. vit-5, vit-1, vit-4, vit-3, vit-6
S.c. SWCP
D.m. RFABP
R.n. MUC5AC
M.m. 3110056H04RIK, VWF
H.s. BMPER, FCGBP
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other ReferencesMatyash, V., Geier, C., Henske, A., Mukherjee, S., Hirsh, D., Thiele, C., Grant, B., Maxfield, F. R., and Kurzchalia, T. V. (2001). Distribution and transport of cholesterol in Caenorhabditis elegans. Mol Biol Cell 12, 1725-36. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=vit-2
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180781
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi