Namevit-5
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 fer(15); fem-1(hc17)
Descriptionvit-5 was identified in a genomic screen for genes that are differentially transcribed in daf-16 and daf-2 RNAi animals (Murphy et al., 2003). RNAi of vit-5 increases life-span by 20%.
Gene Functionunknown
Other PhenotypesVit-5 (Vitellogenin 5) is a 170 kDa yolk protein that functions in embryogenesis and in the lipoprotein formation and oxidation pathways during germ line development.
HomologsC.e. vit-4, vit-3, vit-2, vit-1, vit-6
D.m. RFABP
M.m. 3110056H04RIK, TECTA, ZAN ...
H.s. BMPER, TECTA, FCGBP ...
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-83. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=vit-5
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180630
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray, transcription, genomics, gene expression, RNAi