OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRNAi
DescriptionRNAi of hsp-16 has no effect on adult life-span (Morley and Morimoto, 2003). RNAi of hsp-16 slightly shortens the long life-span of age-1(hx546) animals.
Overexpression of hsp-16 extends life-span (Walker and Lithgow, 2003).
Gene FunctionMolecular chaperone.
Other PhenotypesHsp-16 is a transcriptional target of hsf-1.
Primary ReferenceMorley, J. F., and Morimoto, R. I. (2003). Regulation of longevity in C. elegans by heat shock factor and molecular chaperones. Mol Biol Cell. [Abstract]
Other ReferencesWalker, G. A., and Lithgow, G. J. (2003). Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2, 131-9. [Abstract]
Relevant LinksWormBase:
Keywordsheat shock, stress resistance, worm, insulin, signaling