InterventionDietary restriction of coenzyme Q
Alternate Name
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeN/A
StrainCanton S, Oregon R
DescriptionFlies fed yeast defective in coenzyme Q production (coq3 delta) or yeast defective for respiratory function but CoQ replete had a shorter life-span than flies fed wild type yeast (Palmer and Sackton, 2003).
These results are interpreted to suggest that dietary restriction of CoQ does not extend life-span in flies. Dietary restriction of CoQ has been found to extend life-span in worms (Larsen and Clarke, 2002).
Gene FunctionN/A
Other PhenotypesFlies fed yeast deficient for coQ production showed a faster age-associated decline in cytochrome c activity (Palmer and Sackton, 2003).
Homologs
Primary ReferencePalmer, M. R., and T. B. Sackton, 2003 The effects of dietary coenzyme Q on Drosophila life span. Aging Cell 2: 335.
Other ReferencesLarsen, P. L., and C. F. Clarke, 2002 Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science 295: 120-123.
Relevant Links
Keywordsmetabolism, signaling, mitochondria, fly, oxidative stress, ROS