Namebsk
OrganismDrosophila melanogaster
Aging PhenotypeCorrelation
Allele TypeN/A
StrainOreR, ry506, armGAL4, elavGAL4
DescriptionIncreased JNK pathway activity correlates with increased life-span and enhanced resistance to oxidative stress in flies (Wang et al., 2003).
See database entries puc, hep, and hsp68.
Gene FunctionStress activated protein kinase. MAP kinase.
Other PhenotypesActivation of JNK induces oxidative stress resistance.
Homologs
Primary ReferenceWang, M. C., D. Bohmann and H. Jasper, 2003 JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila. Dev Cell 5: 811-816. [Abstract]
Other References
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0000229
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=44801
Keywordsstress activated protein kinase, oxidative stress, fly