OrganismDrosophila melanogaster
Aging PhenotypeCorrelation
Allele TypeN/A
StrainOreR, ry506, armGAL4, elavGAL4
DescriptionIncreased JNK pathway activity correlates with increased life-span and enhanced resistance to oxidative stress in flies (Wang et al., 2003).
See database entries puc, hep, and hsp68.
Gene FunctionStress activated protein kinase. MAP kinase.
Other PhenotypesActivation of JNK induces oxidative stress resistance.
Primary ReferenceWang, M. C., D. Bohmann and H. Jasper, 2003 JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila. Dev Cell 5: 811-816. [Abstract]
Other References
Relevant LinksFlyBase:
Keywordsstress activated protein kinase, oxidative stress, fly