Namehep
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
Strainelav-GAL4
DescriptionNeuronal overexpression of hep significantly extends median (~50%) and maximum (~25%) life-span (Wang et al., 2003)
Gene FunctionJNK kinase that activates JNK.
Other PhenotypesA hypomorphic allele of hep (hep1) largely prevents the life-span extension caused by puc heterozygosity.
Homologs
Primary ReferenceWang, M. C., D. Bohmann and H. Jasper, 2003 JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila. Dev Cell 5: 811-816. [Abstract]
Other References
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0010303
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=32256
Keywordsstress activated kinase, oxidative stress, fly