OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainOreR, ry506
DescriptionFlies heterozygous for either of two loss of function alleles of puc (pucA251.1 or pucE69) show significant extensions of both median and maximum life-span (Wang et al., 2003).
Heterozygosity for puc only modestly extends life-span in flies carrying a hypomorphic allele of the JNK kinase hep (Wang et al., 2003).
Gene FunctionJNK-specific phosphatase that downregulates the JNK pathway (Martin-Blanco et al., 1998).
Other PhenotypesPuc heterozygotes do not differ siginificantly from wild type controls for body size, reproductive activity or developmental timing, but do show increased resistance to oxidative stress and starvation (Wang et al., 2003).
Primary ReferenceWang, M. C., D. Bohmann and H. Jasper, 2003 JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila. Dev Cell 5: 811-816. [Abstract]
Other ReferencesMartin-Blanco, E., A. Gampel, J. Ring, K. Virdee, N. Kirov et al., 1998 puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev 12: 557-570. [Abstract]
Relevant LinksFlyBase:
Keywordsstress activated kinase, oxidative stress, fly