InterventionPrevention of flight
Alternate Name
OrganismMusca domestica
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainUnknown
DescriptionPrevention of flight activity (by confining the flies to small jars) decreased the rate of oxygen utilization and almost tripled their life-span as compared to those permitted to fly (Yan and Sohal, 2000).
Gene FunctionN/A
Other PhenotypesThe rate of mitochondrial hydrogen peroxide generation at various ages was lower in the low activity flies than in the high activity flies (Yan and Sohal, 2000). Oxidative damage to the mitochondrial proteins adenine nucelotide translocase and aconitase was decreased in low activity flies, and the loss in their functional activity occurring with age was retarded.
Homologs
Primary ReferenceYan, L. J., and R. S. Sohal, 2000 Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins. Free Radic Biol Med 29: 1143-1150. [Abstract]
Other References
Relevant Links
Keywordsfly, housefly, metabolism, oxidative stress, mitochondria, exercise