NameEF-1
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainN/A
DescriptionDrosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies (Shepherd et al., 1989).
Gene FunctionElongation factor 1.
Other PhenotypesThe decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA (Shepherd et al., 1989)
Homologs
Primary ReferenceShepherd, J. C., U. Walldorf, P. Hug and W. J. Gehring, 1989 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Proc Natl Acad Sci U S A 86: 7520-7521. [Abstract]
Other References
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=43736
FlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?content=full-report&FBgn0000557
Keywordsprotein, mRNA, translation, transcription