|Aging Phenotype||Life-span extension|
|Description||Supplementation of food with 50 ppm or 500 ppm Royal Jelly (RJ) increases median life-span of mice by approximately 25% but has no effect on maximum life-span (Inoue et al., 2003). Supplementation with 5 ppm RJ has no effect on life-span.|
|Gene Function||RJ is the principal food of the honeybee queen, produced by the hypo-pharyngael and mandubular glands of worker bees.|
|Other Phenotypes||The mice receiving dietary RJ showed no changes in growth, food intake, or appearance (Inoue et al., 2003).|
Levels of 8-hydroxy-2-deoxyguanosine, a marker of oxidative damage, were reduced in kidney DNA of animals receiving 50 ppm or 500 ppm dietary RJ (Inoue et al., 2003).
|Primary Reference||Inoue, S., S. Koya-Miyata, S. Ushio, K. Iwaki, M. Ikeda et al., 2003 Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp Gerontol 38: 965-969. [Abstract]|
|Keywords||DNA damage, oxidative stress, antioxidant|