InterventionRoyal Jelly
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainC3H/HeJ
DescriptionSupplementation of food with 50 ppm or 500 ppm Royal Jelly (RJ) increases median life-span of mice by approximately 25% but has no effect on maximum life-span (Inoue et al., 2003). Supplementation with 5 ppm RJ has no effect on life-span.
Gene FunctionRJ is the principal food of the honeybee queen, produced by the hypo-pharyngael and mandubular glands of worker bees.
Other PhenotypesThe mice receiving dietary RJ showed no changes in growth, food intake, or appearance (Inoue et al., 2003).
Levels of 8-hydroxy-2-deoxyguanosine, a marker of oxidative damage, were reduced in kidney DNA of animals receiving 50 ppm or 500 ppm dietary RJ (Inoue et al., 2003).
Homologs
Primary ReferenceInoue, S., S. Koya-Miyata, S. Ushio, K. Iwaki, M. Ikeda et al., 2003 Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp Gerontol 38: 965-969. [Abstract]
Other References
Relevant Links
KeywordsDNA damage, oxidative stress, antioxidant