Namebec-1
OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRNAi
StrainN2
DescriptionRNAi of bec-1 shortens median life-span by approximately 14% and prevents life-span extension by daf-2(e1370) (Melendez et al., 2003).
Gene FunctionProtein involved in autophagy.
Other PhenotypesRNAi of bec-1 caused the formation of abnormal dauers in a daf-2(e1370) background (Melendez et al., 2003).
HomologsS.c. VPS30
S.p. Spac20g8.10cp
D.m. CG5429
R.n. BECN1
M.m. BECN1
BECN1
Primary ReferenceMelendez, A., Z. Talloczy, M. Seaman, E. L. Eskelinen, D. H. Hall et al., 2003 Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans. Science 301: 1387-1391. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/misc/etree?name=bec-1&class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177345
Keywordsautophagy, worm, insulin signaling