|Aging Phenotype||Shortened life-span|
|Description||Loss of p53 activity slightly shortens the life-span of flies (Lee et al., 2003). Flies lacking Dmp53 survived well up to 50 days, but mortality rates increased relative to wild type at later ages.|
|Gene Function||p53 is a tumor suppressor/DNA-binding transcription factor important for apoptosis in mammals.|
|Other Phenotypes||Animals lacking Dmp53 are extremely sensitive to irradiation (Lee et al., 2003).|
Mice that are heterozygous for an allele of p53 that removes the 5` portion of the protein demonstrate decreased cancer, premature aging phenotypes, and shortened life span (Tyner et al., 2002).
|Primary Reference||Lee, J. H., E. Lee, J. Park, E. Kim, J. Kim et al., 2003 In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett 550: 5-10. [Abstract]|
|Other References||Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Hee Park, S., Thompson, T., Karsenty, G., Bradley, A., and Donehower, L. A. [Abstract]|
|Keywords||p53, tumor suppressor, cancer, apoptosis|