OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionLoss of p53 activity slightly shortens the life-span of flies (Lee et al., 2003). Flies lacking Dmp53 survived well up to 50 days, but mortality rates increased relative to wild type at later ages.
Gene Functionp53 is a tumor suppressor/DNA-binding transcription factor important for apoptosis in mammals.
Other PhenotypesAnimals lacking Dmp53 are extremely sensitive to irradiation (Lee et al., 2003).
Mice that are heterozygous for an allele of p53 that removes the 5` portion of the protein demonstrate decreased cancer, premature aging phenotypes, and shortened life span (Tyner et al., 2002).
HomologsH.s. TP53
M.m. TRP53
D.m. TP53
Primary ReferenceLee, J. H., E. Lee, J. Park, E. Kim, J. Kim et al., 2003 In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett 550: 5-10. [Abstract]
Other ReferencesTyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Hee Park, S., Thompson, T., Karsenty, G., Bradley, A., and Donehower, L. A. [Abstract]
Relevant Links
Keywordsp53, tumor suppressor, cancer, apoptosis