NameLmSIR2
OrganismLeishmania infantum
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainMHOM/MA/67/ITMAP-263
DescriptionOverexpression of LmSir2p, which is homologous to yeast Sir2 protein, results in a significant increase survival of the vertebrate stage of L. infantum under normal axenic culture conditions, but has no effect on survival of the insect stage of the parasite (Vergnes et al., 2002).
Gene FunctionPresumed protein deacetylase based on homology to yeast Sir2p.
Other PhenotypesLmSIR2p is mainly localized within the cytoplasm (Vergnes et al., 2002).
Overexpression of Sir2 proteins has been shown to increase life-span in yeast (Kaeberlein et al., 1999) and worms (Tissenbaum and Guarente, 2001).
HomologsS.c. SIR2, HST1, HST2, HST3, HST4
S.p. Spbc16D10.07c, Spcc132.02, hst4
C.e. Sir-2.1, F46G10.3, F46G10.7, C06A5.3
D.m. sir2, CG6284, CG3187
M.m. SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6
H.s. SIRT1, SIRT3, SIRT2, SIRT5, SIRT4
R.n. SIRT2
Primary ReferenceVergnes, B., D. Sereno, N. Madjidian-Sereno, J. L. Lemesre and A. Ouaissi, 2002 Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death. Gene 296: 139-150. [Abstract]
Other ReferencesKaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Tissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230. [Abstract]
Relevant Links
Keywordssilencing, sirtuin, apoptosis, parasite