InterventionButein
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainPSY316
DescriptionTreatment of cells with butein increases mean replicative life-span by approximately 31% (Howitz et al., 2003).
Gene Function
Other PhenotypesButein is an activator of SIR2-family member enzymes (Howitz et al., 2003).
Homologs
Primary ReferenceHowitz, K. T., K. J. Bitterman, H. Y. Cohen, D. W. Lamming, S. Lavu et al., 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.