InterventionResveratrol
Alternate Name
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainPSY316
DescriptionResveratrol has no effect on chronological life-span, however treatment of cells with 10 uM resveratrol increases mean replicative life-span by approximately 70% (Howitz et al., 2003).
Gene FunctionResveratrol is an antioxidant found in red wine that also activates Sirtuins.
Other Phenotypes
Homologs
Primary ReferenceHowitz, K. T., K. J. Bitterman, H. Y. Cohen, D. W. Lamming, S. Lavu et al., 2003 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature Advance online publication. 24 August 2003.
Other References
Relevant Links
Keywordscaloric restriction, calorie restriction, CR, rDNA, silencing, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae, chromatin, DNA, metabolism, NAD, transcription, chronological life-span, stationary phase