InterventionResveratrol
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainPSY316
DescriptionTreatment of cells with 10 uM resveratrol was reported to increase mean replicative life-span by approximately 70% (Howitz et al., 2003). A more recent study failed to reproduce these findings and reported that resveratrol has no effect on lifespan in three different strain backgrounds, including PSY316 (Kaeberlein et al., 2005).
Resveratrol has no effect on chronological life-span.
Gene FunctionResveratrol is an antioxidant found in red wine.
Other PhenotypesLife-span extension by resveratrol requires SIR2 and resveratrol fails to further extend the life-span of calorically restricted cells (Howitz et al., 2003).
Homologs
Primary ReferenceHowitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., et al. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-1 [Abstract]
Other ReferencesKaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S., Napper, A., Curtis, R., Distefano, P. S., Fields, S., et al. (2005). Substrate specific activation fo sirtuins by resveratrol. J Biol Chem. [Abstract]
Relevant Links
Keywordscaloric restriction, calorie restriction, CR, rDNA, silencing, recombination, yeast, replicative senescence, Saccharomyces, cerevisiae, chromatin, DNA, metabolism, NAD, ranscription