|Aging Phenotype||Shortened life-span|
|Description||Mean life-span in 11 untreated, affected individuals homozygous for a deletion at the GH-1 locus was significantly shorter (P < 0.05) than in unaffected siblings or the general population (Besson et al., 2003).|
|Gene Function||Human growth hormone.|
|Other Phenotypes||Individuals homozygous for the GH-1 deletion demonstrate hereditary dwarfism (Besson et al., 2003).|
The short life-span of humans defective for GH production is different from mutations that decrease growth hormone signaling and cause dwarfism in rodents, which have been generally found to increase life-span (e.g. see GH, GHR, and Ghrhr).
|Primary Reference||Besson, A., S. Salemi, S. Gallati, A. Jenal, R. Horn et al., 2003 Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab 88: 3664-3667. [Abstract]|
|Relevant Links||OMIM: http://www.ncbi.nlm.nih.gov:80/entrez/dispomim.cgi?id=139250|
|Keywords||hormonal, signaling, insulin, dwarf, rat, mouse, pituitary, mouse|