InterventionVitamin C
Alternate Nameascorbic acid
OrganismHomo sapiens (cell culture)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainHE49, NYaKe, WS3RGB
DescriptionAddition of ascorbic acid phospholic ester magnesium salt at 200 micromolar to growth medium increased the replicative life-spans of human embryonic cells (HE49), adult skin fibroblasts (NYaKe), and cells derived from a Werner Syndrome patient (WS3RGB) by 15%, 11%, and 67%, respectively .
Gene Function
Other Phenotypes
Primary ReferenceKashino, G., Kodama, S., Nakayama, Y., Suzuki, K., Fukase, K., Goto, M., and Watanabe, M. (2003). Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells, Free Radic Biol Med 35, 438-43. [Abstract]
Other References
Relevant Links
Keywordsnutrition, antioxidant, oxidative stress, dietary supplementation, replicative senescence, cell culture