OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2 rrf-3(pk1426)
DescriptionRNAi of ins-7 increases life-span by 55% at 20C in this background (Murphy et al., 2003).
Gene FunctionInsulin/IGF-1-like peptide
Other PhenotypesRNAi of ins-7 does not further extend life-span in a daf-2 mutant (Murphy et al., 2003). Based on microarray analysis, ins-7 is repressed in animals with reduced daf-2 activity and elevated in animals with reduced daf-16 activity.
Primary ReferenceMurphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans, Nature 424, 277-83. [Abstract]
Other References
Relevant LinksLocusLink:
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, dauer, metabolism, daf-16, daf-2, microarray