Interventionovary transplantation
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainCBA
DescriptionTransplantation of young ovaries into old ovariectomized mice resulted in a significant increase in life-span (20% death in transplant females versus 65% death in ovariectomized controls during the 300-day period following transplantation) (Cargill et al., 2003).
Gene FunctionN/A
Other Phenotypes11-month transplant females resumed oestrus and continued to cycle for several months beyond the age of reproductive senescence in control females (Cargill et al., 2003).
Homologs
Primary ReferenceCargill, S. L., Carey, J. R., Muller, H. G., and Anderson, G. (2003). Age of ovary determines remaining life expectancy in old ovariectomized mice, Aging Cell 2, 185-90. [Abstract]
Other References
Relevant Links
Keywordsreproduction, hormonal, hormone, ovary, ovaries, gonad, sex