NamePrdx1
OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainB6 x 129SvEv
DescriptionPrdx1 -/- mice have a life span significantly shorter than +/+ or +/- littermates (Neuman et al., 2003).
Gene FunctionPeroxiredoxin. Antioxidant enzyme that scavenges peroxides and uses thioredoxin as an electron donor.
Other PhenotypesPrdx1 -/- mice develop severe hemolytic anemia and several types of malignant cancers starting at about 9 months of age (Neuman et al., 2003).
HomologsS.c. TSA1, TSA2, PRX1
S.p. TPX1
C.e. F09E5.15, R07E5.2
D.m. JAFRAC1, CG1633, JAFRAC2
R.n. PRDX1, PRDX2, PRDX4, PRDX3
M.m. PRDX2, PRDX4, PRDX3
H.s. PRDX1, PRDX2, PRDX4, PRDX3
Primary ReferenceNeuman, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., and Van Etten, R. A. (2003). Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumor suppressio
Other References
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=18477
Keywordsantioxidant, ROS, reactive oxygen species, oxidative stress